“Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage”. Further it is important to illustrate the scientific importance of the understanding of neuronal mechanisms involved in nociception, the patients response to pain, and the resulting pain management. It helps validate what the practitioner is administering, in this case physical treatment-Chiropractic. Patients recognise that they have received the appropriate diagnosis and treatment for their condition. Chiropractic emphasises the role of proper functioning of the nervous system to maintain proper health. Therefore it is of paramount importance that this report of our current understanding of the neurobiology of pain mechanisms, in terms of neurotransmitters, receptors and impulse transmission benefit Chiropractic treatment.